NADPH
NADPH (pronounced as "en-ay-dee-pee-aych") is an acronym for Nicotinamide Adenine Dinucleotide Phosphate (pronounced as "nik-oh-tin-uh-mide ad-uh-neen di-nu-klee-uh-tide fos-fate").
Etymology
The term NADPH is derived from its full form, Nicotinamide Adenine Dinucleotide Phosphate. The term itself is a combination of several words. 'Nicotinamide' is derived from 'nicotine', a compound found in tobacco, and 'amide', a type of organic compound. 'Adenine' is one of the four bases in DNA and RNA, and 'Dinucleotide' refers to a type of molecule that consists of two nucleotides. 'Phosphate' is a chemical compound that contains the element phosphorus.
Definition
NADPH is a coenzyme used in anabolic reactions, which involve the building up of large molecules from smaller ones, in cells. It is a product of the Pentose Phosphate Pathway and is used in Reactive Oxygen Species (ROS) detoxification, Nitric Oxide Synthase activity, and in the synthesis of Fatty Acids and Cholesterol.
Related Terms
- Coenzyme: A non-protein compound that is necessary for the functioning of an enzyme.
- Anabolic Reactions: Metabolic pathways that construct molecules from smaller units.
- Pentose Phosphate Pathway: A metabolic pathway parallel to glycolysis that generates NADPH and pentoses.
- Reactive Oxygen Species: Chemically reactive chemical species containing oxygen.
- Nitric Oxide Synthase: An enzyme that catalyzes the production of nitric oxide (NO).
- Fatty Acids: Carboxylic acids with long aliphatic chains which are either saturated or unsaturated.
- Cholesterol: A type of lipid molecule and is biosynthesized by all animal cells.
See Also
External links
- Medical encyclopedia article on NADPH
- Wikipedia's article - NADPH
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