Iodomethane

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Iodomethane, also known as methyl iodide and by its IUPAC name as iodomethane, is a chemical compound with the chemical formula CH3I. It is a dense, colorless, volatile liquid. In organic chemistry, it is used as a methylating agent, a substance that transfers a methyl group (CH3) to another molecule. Due to its potential health risks, including being a suspected carcinogen, its use is regulated in many countries.

Properties

Iodomethane is a halogenated organic compound in which a methyl group is bonded to an iodine atom. It has a boiling point of 42-43 °C and a melting point of -66.5 °C. Being denser than water, it is soluble in organic solvents but only slightly soluble in water.

Synthesis

Iodomethane can be synthesized through several methods. One common method involves the reaction of methanol with iodine in the presence of red phosphorus. This reaction produces iodomethane and phosphorus acid as a byproduct.

Uses

In organic synthesis, iodomethane is primarily used as a methylating agent. It is involved in various chemical reactions, including the methylation of carboxylic acids, phenols, and amines. It is also used in the preparation of certain pharmaceuticals and pesticides.

Safety

Iodomethane is a toxic compound and is considered to be a potential carcinogen. Exposure to iodomethane can cause serious health issues, including respiratory problems, skin irritation, and damage to the central nervous system. It is important to handle iodomethane with appropriate safety precautions, including the use of personal protective equipment and adequate ventilation.

Regulation

Due to its toxicity and potential health risks, the use and handling of iodomethane are regulated under various international guidelines and regulations. These regulations aim to protect human health and the environment from the adverse effects of iodomethane exposure.

Environmental Impact

Iodomethane can have adverse effects on the environment. It is capable of depleting ozone in the atmosphere and may contribute to ozone layer depletion if released in large quantities.

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Iodomethane

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Contributors: Prab R. Tumpati, MD