Interleukin 36

Interleukin 36 (IL-36) is a group of cytokines that belong to the Interleukin 1 cytokine family. This group includes three agonists, one antagonist, and one receptor. The agonists are IL-36α, IL-36β, and IL-36γ, the antagonist is IL-36Ra, and the receptor is IL-36R.

Function

IL-36 cytokines are involved in the immune response and inflammation. They are produced by keratinocytes and immune cells, and they act on various cells, including dendritic cells, T cells, and macrophages. IL-36 cytokines can stimulate the production of other cytokines and chemokines, and they can promote the proliferation and differentiation of T cells.

Role in disease

IL-36 cytokines have been implicated in several diseases, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. In psoriasis, IL-36 cytokines are overexpressed in the skin, and they contribute to the inflammation and skin thickening that are characteristic of this disease. In rheumatoid arthritis, IL-36 cytokines can stimulate the production of inflammatory mediators in the joints. In inflammatory bowel disease, IL-36 cytokines can promote inflammation in the gut.

Therapeutic potential

Because of their role in inflammation and immune responses, IL-36 cytokines are being investigated as potential targets for the treatment of inflammatory diseases. Several drugs that target IL-36 cytokines are currently in development.

See also

• Interleukin
• Cytokine
• Immune response
• Inflammation
• Psoriasis
• Rheumatoid arthritis
• Inflammatory bowel disease