INO80 complex subunit E

INO80 complex subunit E (INO80E) is a protein that in humans is encoded by the INO80E gene. This protein is a component of the INO80 complex, which is involved in the regulation of DNA repair, transcription, and chromatin remodeling. The INO80 complex plays a critical role in maintaining genomic stability and proper gene expression, making it essential for cellular function and organismal development.

Function

The INO80 complex, including its subunit E, is pivotal in the process of DNA repair, particularly in the repair of double-strand breaks (DSBs) and in the resolution of replication stress. It facilitates access to chromatin by remodeling nucleosomes, thereby allowing repair proteins to access and repair damaged DNA. Furthermore, INO80E, as part of the INO80 complex, is involved in transcription regulation by modulating the accessibility of transcription factors to their target genes. This regulation is crucial for the proper expression of genes involved in cell cycle progression, differentiation, and response to environmental stimuli.

Structure

INO80E is one of several subunits of the INO80 chromatin remodeling complex. The structure of INO80E, as with other subunits, contributes to the overall architecture of the INO80 complex, enabling its function in chromatin remodeling. The precise structure of INO80E and its interaction with other subunits within the complex are subjects of ongoing research, aiming to elucidate the mechanisms by which the INO80 complex influences chromatin dynamics and gene expression.

Clinical Significance

Alterations in the expression or function of the INO80 complex, including INO80E, have been implicated in various human diseases. Given its role in DNA repair and gene expression, dysregulation of INO80E can contribute to the development of cancer by promoting genomic instability and aberrant expression of oncogenes and tumor suppressor genes. Research is ongoing to understand the potential of targeting the INO80 complex in cancer therapy, either by modulating its activity or by exploiting its functions for the delivery of therapeutic agents.

Research Directions

Current research on INO80E and the INO80 complex focuses on understanding their roles in chromatin remodeling, DNA repair, and transcription regulation in more detail. Studies are also exploring the potential therapeutic implications of targeting the INO80 complex in various diseases, including cancer. The development of small molecule inhibitors that can specifically modulate the activity of the INO80 complex presents a promising avenue for therapeutic intervention.

See Also

• Chromatin remodeling
• DNA repair
• Transcription (genetics)
• Genomic stability

References

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INO80 complex subunit E

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  INO80 stabilizes replication forks and counteracts mislocalization of H2A.Z