Hepatocyte nuclear factor 4 alpha

From WikiMD's WELLNESSPEDIA

Hepatocyte nuclear factor 4 alpha (HNF4A), also known as nuclear receptor subfamily 2 group A member 1 (NR2A1), is a nuclear receptor that in humans is encoded by the HNF4A gene. It is a member of the nuclear receptor superfamily of transcription factors.

Function[edit]

HNF4A is a nuclear transcription factor that binds DNA as a homodimer. It controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines.

Clinical significance[edit]

Mutations in this gene have been associated with monogenic diabetes mellitus of the young type 1 (MODY1) and hepatocellular adenoma.

Interactions[edit]

HNF4A has been shown to interact with:

See also[edit]

References[edit]


External links[edit]

Stub icon

This medical article is a stub. You can help WikiMD by expanding the page.


Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Retrieved from "https://wikimd.org/index.php?title=Hepatocyte_nuclear_factor_4_alpha&oldid=6508687"