HT1080

HT1080 is a cell line derived from a fibrosarcoma patient. It is commonly used in biological research due to its high transfection efficiency and robust growth characteristics.

History

The HT1080 cell line was established in 1972 from the fibrosarcoma of a 35-year-old male. The cells are adherent and have a fibroblast-like morphology.

Characteristics

HT1080 cells are highly transfectable, making them a popular choice for gene expression studies. They are also used in cancer research, as they are derived from a malignant tumor and exhibit many of the hallmarks of cancer, including rapid growth and resistance to apoptosis.

Applications

Due to their high transfection efficiency, HT1080 cells are often used in studies involving gene therapy. They are also used in drug discovery and toxicology studies, as they can be used to test the effects of potential drugs on cancer cells.

Culture Conditions

HT1080 cells are typically cultured in Eagle's Minimum Essential Medium (EMEM) supplemented with 10% fetal bovine serum (FBS). They are grown at 37 degrees Celsius in a humidified atmosphere containing 5% CO2.

References

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  HT1080