HPGD

HPGD is a human gene that encodes for the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). This enzyme is primarily responsible for the biological inactivation of prostaglandins, which are lipid compounds that have diverse hormone-like effects in animals.

Function

The enzyme encoded by the HPGD gene is responsible for catalyzing the NAD+-linked oxidation of 15 (S)-hydroxyl groups of prostaglandins and lipoxins. Prostaglandins are a group of physiologically active lipid compounds that have diverse hormone-like effects, such as regulating the contraction and relaxation of smooth muscle tissue. Lipoxins are a series of eicosanoid metabolites that are involved in the resolution phase of the inflammatory response.

Clinical significance

Mutations in the HPGD gene have been associated with primary hypertrophic osteoarthropathy, also known as pachydermoperiostosis. This is a rare genetic disorder characterized by digital clubbing, periostosis, and pachydermia.

In addition, the HPGD gene has been implicated in various types of cancer, including breast, colon, and lung cancer. The enzyme it encodes, 15-PGDH, is often downregulated in these types of cancer, suggesting a potential role in tumorigenesis.

See also

• Prostaglandin
• Lipoxin
• Pachydermoperiostosis
• Cancer

References

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