HDAC11

HDAC11 is a gene that encodes the enzyme histone deacetylase 11 in humans. This enzyme is part of the histone deacetylase family, which plays a crucial role in the regulation of gene expression.

Function

HDAC11 is the most recently identified member of the histone deacetylase family. It is involved in the deacetylation of lysine residues on the nuclear or cytoplasmic proteins, thus regulating cell cycle progression, cell proliferation, and other critical cellular processes.

Structure

The HDAC11 gene is located on the chromosome 3 in humans. It consists of 10 exons and spans approximately 29 kilobases. The encoded protein is 347 amino acids long and has a molecular weight of approximately 39 kilodaltons.

Clinical Significance

Alterations in the expression or activity of HDAC11 have been implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In particular, overexpression of HDAC11 has been observed in certain types of cancer, suggesting that it may serve as a potential therapeutic target.

Research

Research into HDAC11 is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target. Several HDAC inhibitors are currently being investigated for their potential to inhibit HDAC11 and thereby treat diseases associated with its overexpression.

See Also

• Histone deacetylase
• Gene expression
• HDAC inhibitor

References

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