Fusion transcript
Fusion transcript
A Fusion transcript (pronunciation: /ˈfjuːʒən ˈtrænskrɪpt/) is a hybrid mRNA molecule that is the product of a chromosomal translocation, interstitial deletion, or inversion. Fusion transcripts are often associated with cancer, as they can lead to the production of oncogenic fusion proteins.
Etymology
The term "fusion transcript" is derived from the English words "fusion", meaning the process or result of joining two or more things together to form a single entity, and "transcript", which in genetics refers to the process of transcribing DNA into RNA.
Related terms
- Chromosomal translocation: A chromosomal abnormality caused by rearrangement of parts between nonhomologous chromosomes.
- Interstitial deletion: A mutation that occurs when a chromosome breaks in two places and the segment between breaks is lost.
- Inversion (genetics): A chromosome rearrangement in which a segment of a chromosome is reversed end to end.
- Oncogene: A gene that has the potential to cause cancer.
- Fusion protein: A protein created through the joining of two or more genes that originally coded for separate proteins.
See also
External links
- Medical encyclopedia article on Fusion transcript
- Wikipedia's article - Fusion transcript
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