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Summary
DescriptionIdealized curves of estradiol levels after injection of different estradiol esters in women.png
English: Levels of estradiol over a period of 30 days after a single intramuscular injection of different estradiol esters in women. The estradiol esters included estradiol benzoate, estradiol valerate, estradiol cypionate, and estradiol enanthate. In all of the cases except for estradiol benzoate, the estradiol ester was injected along with a long-lasting parenteral progestin. The level profiles are simplified curves based on data from clinical studies of these estradiol esters in combined injectable contraceptives. Each curve was generated with four data points, including day 0; the day with the highest recorded level; a third point a variable number of days after the peak day; and day 30. Then, the points were connected with smoothed lines. The measurements from which the points were drawn were also taken at 24-hour intervals. Hence, the true peak levels and time to peak values are not represented in this graph, and the peak levels may have been significantly higher than what is shown.
(October 1987). "A multicentered pharmacokinetic, pharmacodynamic study of once-a-month injectable contraceptives. I. Different doses of HRP112 and of DepoProvera. World Health Organization Task Force on Long-acting Systemic Agents for Fertility Regulation". Contraception36 (4): 441–57. DOI:10.1016/0010-7824(87)90093-X. PMID2964992.
World Health Organization. Task Force on Long-Acting Systemic Agents for Fertility Regulation, Special Programme of Research, Development and Research Training in Human Reproduction: A multicentred pharmacokinetic, pharmacodynamic study of once-a-month injectable contraceptives. II. Different doses of HRP 102 and of norethisterone enanthate (in preparation).
Seems to have never actually been published. However, it appears to be the same study as this one which was published in Chinese:
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