Factor V
Factor V
Factor V (pronounced: "factor five") is a protein of the coagulation system, usually existing in an inactive form, which is transformed into active form (Factor Va) by thrombin during the process of blood coagulation.
Etymology
The term "Factor V" is derived from the fact that it is one of the factors necessary for blood to clot. It was discovered in the mid-20th century during a series of experiments aimed at discovering all of the components necessary for blood coagulation.
Function
Factor V is a critical component of the blood coagulation cascade. It is an essential cofactor that enables the enzyme prothrombin to be converted into thrombin, which in turn helps convert fibrinogen into fibrin, leading to blood clot formation.
Related Terms
- Factor V Leiden: A mutation of one of the clotting factors in the blood called factor V. This mutation can increase your chance of developing abnormal blood clots.
- Prothrombin: An enzyme in the blood plasma that is converted into active thrombin during coagulation.
- Thrombin: An enzyme in blood plasma that causes the clotting of blood by converting fibrinogen to fibrin.
- Fibrinogen: A protein in the blood plasma that is essential for the coagulation of blood.
- Fibrin: An insoluble protein formed from fibrinogen during the clotting of blood. It forms a fibrous mesh that impedes the flow of blood.
See Also
External links
- Medical encyclopedia article on Factor V
- Wikipedia's article - Factor V
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