FOXH1

FOXH1 is a protein that in humans is encoded by the FOXH1 gene. This protein is a member of the Forkhead box family of transcription factors, which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for embryonic development.

Function

The FOXH1 gene encodes a protein that functions as a transcription factor. Transcription factors are proteins that help turn specific genes "on" or "off" by binding to nearby DNA. This protein is part of the forkhead box (FOX) family, a diverse group of transcription factors that play important roles in areas such as cell division, tissue-specific gene expression, and development.

The FOXH1 protein interacts with Smad proteins and acts as a co-factor to stimulate the transcription of specific target genes. In particular, it plays a crucial role in the TGF-beta signaling pathway, which is involved in cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions.

Clinical significance

Mutations in the FOXH1 gene have been associated with several congenital disorders, including VACTERL association, a non-random association of birth defects that affects multiple parts of the body. The FOXH1 gene may also play a role in the development of some types of cancer.

See also

• Forkhead box
• Transcription factor
• Smad (protein)
• TGF-beta signaling pathway
• VACTERL association

References

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