Estradiol pivalate
Estradiol pivalate is a synthetic, steroidal estrogen that is used in hormone therapy. It is an ester of estradiol, the primary female sex hormone. Estradiol pivalate is used primarily in the treatment of menopausal symptoms such as hot flashes and osteoporosis. It is also used in hormone replacement therapy for transgender women.
Pharmacology[edit]
Estradiol pivalate is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is administered via injection, and has a longer duration of action than estradiol itself due to its esterification.
Medical uses[edit]
Estradiol pivalate is used primarily to treat symptoms of menopause, such as hot flashes and osteoporosis. It is also used in hormone replacement therapy for transgender women, to help them develop secondary sexual characteristics.
Side effects[edit]
Like all estrogens, estradiol pivalate can have a number of side effects. These can include nausea, bloating, breast tenderness, and an increased risk of blood clots and stroke. Long-term use can also increase the risk of certain types of cancer, including breast cancer and endometrial cancer.
See also[edit]
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Estradiol pivalate[edit]
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Vaginal changes with estradiol pivalate in oil solution by intramuscular injection in women
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