Estradiol dibutyrate

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Estradiol Dibutyrate

Estradiol dibutyrate (pronunciation: es-tra-DYE-ol dye-BYOO-ti-rate) is a synthetic, steroidal estrogen that is used in medicine, specifically in hormone replacement therapy for menopausal symptoms and in hormonal contraception. It is an ester of estradiol, the primary female sex hormone.

Etymology

The term "estradiol" is derived from estrus (Latin for "gadfly" or "frenzy"), -diol (a chemical term denoting a certain type of organic compound), and dibutyrate (indicating the presence of two butyrate ester groups).

Pharmacology

Estradiol dibutyrate is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is more lipophilic (fat-soluble) than estradiol itself, which allows it to be absorbed more efficiently when taken orally.

Clinical Use

Estradiol dibutyrate is used in hormone replacement therapy to treat symptoms of menopause such as hot flashes and vaginal dryness. It is also used in some forms of hormonal contraception.

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