Erythroplakia

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Erythroplakia
Synonyms
Pronounce	N/A
Specialty	Oral and maxillofacial pathology, Dentistry
Symptoms	Red patch in the mouth, often asymptomatic
Complications	Oral cancer
Onset
Duration
Types
Causes	Unknown, but associated with tobacco and alcohol use
Risks	Smoking, alcohol consumption, human papillomavirus (HPV) infection
Diagnosis	Biopsy and histopathological examination
Differential diagnosis	Leukoplakia, Lichen planus, Candidiasis
Prevention	Avoidance of risk factors such as tobacco and alcohol
Treatment	Surgical excision, laser therapy
Medication
Prognosis	Variable, depends on histopathological findings
Frequency	Rare
Deaths

Erythroplakia is a clinical term to describe any red patch on the mucous membrane in the mouth that cannot be attributed to any other pathology. It is considered a potentially malignant disorder, with a high rate of malignant transformation to oral squamous cell carcinoma.

Etiology

The exact cause of erythroplakia is unknown, but it is often associated with chronic irritation and tobacco use, both smoked and smokeless. It is also associated with alcohol use and poor oral hygiene. Human papillomavirus (HPV) infection has also been implicated in some cases.

Clinical Features

Erythroplakia presents as a bright red patch that cannot be characterized clinically or pathologically as any other definable disease. The lesion is usually flat or slightly raised and is often velvety in texture. It is most commonly found on the floor of the mouth, tongue, and soft palate.

Diagnosis

Diagnosis of erythroplakia is based on clinical examination and biopsy. Histopathological examination of the biopsy specimen is necessary to confirm the diagnosis and to rule out other conditions such as lichen planus, pemphigus vulgaris, and squamous cell carcinoma.

Treatment

The treatment of choice for erythroplakia is surgical excision. This can be done using traditional surgical techniques or with a laser. In some cases, if the lesion is too large or in a difficult location, it may be treated with cryotherapy or photodynamic therapy.

Prognosis

The prognosis for erythroplakia is generally good if it is detected and treated early. However, because of the high rate of malignant transformation, regular follow-up is essential.

See Also

• Oral cancer
• Oral pathology
• Oral and maxillofacial surgery

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