Eprinomectin

Eprinomectin is a broad-spectrum antiparasitic agent primarily used in veterinary medicine. It is a member of the macrocyclic lactone class of antiparasitics, which also includes other drugs such as ivermectin and moxidectin. Eprinomectin is particularly effective against a variety of parasites, including nematodes, arthropods, and ectoparasites.

History

Eprinomectin was first developed by the pharmaceutical company Merck & Co. in the late 20th century. It was designed to be a more potent and safer alternative to earlier macrocyclic lactones.

Pharmacology

Eprinomectin works by binding to glutamate-gated chloride channels in the nerve and muscle cells of parasites. This binding causes an influx of chloride ions, leading to hyperpolarization of the cell membrane and paralysis and death of the parasite.

Eprinomectin is unique among macrocyclic lactones in that it is not systemically absorbed when administered topically. This means it remains on the surface of the animal's skin and in the gastrointestinal tract, where it can effectively kill parasites without entering the animal's bloodstream.

Uses

Eprinomectin is used in the treatment and prevention of parasitic infections in a variety of animals, including cattle, sheep, and goats. It is particularly effective against gastrointestinal nematodes, lungworms, and certain types of mites and lice.

Safety

Eprinomectin is generally considered safe for use in most animals. However, it should not be used in animals with a known hypersensitivity to macrocyclic lactones. Side effects are rare but can include skin irritation at the site of application.

See Also

• Antiparasitic
• Macrocyclic lactone
• Veterinary medicine

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  Eprinomectin B1a skeletal structure

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  Eprinomectin B1b skeletal structure