Eomesodermin

Eomesodermin (also known as Eomes) is a T-box transcription factor that plays a crucial role in the development and differentiation of various cell types during embryogenesis. It is encoded by the Eomes gene in humans.

Function

Eomesodermin is primarily involved in the formation of mesoderm and endoderm during early embryonic development. It is also essential for the differentiation of CD8+ T cells and natural killer cells, which are critical components of the immune system.

Structure

The Eomes gene is located on the long (q) arm of chromosome 3 at position 21.3. The protein encoded by this gene belongs to the T-box family of transcription factors, characterized by a DNA-binding domain known as the T-box.

Role in Disease

Mutations in the Eomes gene have been associated with various diseases. For example, a lack of Eomesodermin has been linked to congenital heart defects, neural tube defects, and immune system disorders.

Research

Research on Eomesodermin is ongoing, with studies focusing on its role in immune response, embryonic development, and disease pathogenesis. Understanding the function of Eomesodermin could lead to new treatments for a variety of diseases.

See Also

• T-box
• Transcription factor
• Embryogenesis
• CD8+ T cells
• Natural killer cells
• Immune system
• Chromosome 3
• Congenital heart defects
• Neural tube defects
• Immune system disorders

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  T-box DNA binding domain

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  Microcephaly comparison