Endothion
Endothion is an organophosphate insecticide that is primarily used in the control of pests in a variety of agricultural settings. It is a potent neurotoxin that acts by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine in the nervous system. This results in overstimulation of the nerves, leading to symptoms of poisoning.
History
Endothion was first synthesized in the mid-20th century as part of a broader effort to develop new insecticides that could be used to protect crops and livestock. It was quickly recognized for its potent insecticidal properties and has been widely used in agriculture ever since.
Use in Agriculture
Endothion is used to control a wide range of pests, including aphids, mites, and whiteflies. It is typically applied as a spray, either directly onto the plants or onto the soil around them. The insecticide is absorbed by the plants and then ingested by the pests when they feed on the plants.
Health Effects
Exposure to endothion can cause a range of health effects, depending on the level and duration of exposure. At low levels, exposure can cause symptoms such as nausea, vomiting, and diarrhea. At higher levels, exposure can cause more serious effects, including seizures, respiratory failure, and even death.
Environmental Impact
Like many organophosphate insecticides, endothion is highly toxic to non-target organisms, including birds, fish, and beneficial insects. It is also highly persistent in the environment, meaning that it can remain in the soil and water for long periods of time after it has been applied.
Regulation
Due to its high toxicity and environmental persistence, the use of endothion is heavily regulated in many countries. In the United States, for example, the Environmental Protection Agency (EPA) has set strict limits on the use of endothion in agriculture.
See Also
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Contributors: Prab R. Tumpati, MD