Dermoepidermal junction
Dermoepidermal Junction
The Dermoepidermal Junction (pronunciation: der-mo-epi-der-mal junc-tion) is a specialized area of the skin where the dermis and epidermis meet and interact.
Etymology
The term "Dermoepidermal Junction" is derived from the combination of the words "dermis" and "epidermis", which are the two primary layers of the skin, and "junction", which refers to the point where two things join.
Definition
The Dermoepidermal Junction is a complex structure that serves as a physical and biological interface between the dermis and epidermis. It plays a crucial role in skin homeostasis, providing mechanical resistance and mediating the exchange of molecules and signals between the two skin layers.
Structure
The Dermoepidermal Junction is composed of the basal lamina, a thin layer of extracellular matrix, and the hemidesmosomes, which are specialized structures that anchor the epidermis to the dermis. The basal lamina is further divided into the lamina lucida and the lamina densa, each with specific functions and components.
Function
The Dermoepidermal Junction has several important functions. It provides structural integrity to the skin, preventing the layers from separating under mechanical stress. It also acts as a selective barrier, controlling the passage of molecules and cells between the dermis and epidermis. Furthermore, it plays a role in signal transduction, influencing cell proliferation, differentiation, and migration.
Related Terms
- Dermis: The thick layer of living tissue below the epidermis that forms the true skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.
- Epidermis: The outermost layer of the skin, providing a waterproof barrier and creating our skin tone.
- Basal Lamina: A layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits.
- Hemidesmosomes: Specialized cell junctions that connect intermediate filaments of the cytoskeleton with the extracellular matrix.
External links
- Medical encyclopedia article on Dermoepidermal junction
- Wikipedia's article - Dermoepidermal junction
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