Depsipeptides

Depsipeptides

Depsipeptides (pronounced: /ˈdɛpsiˌpiːtaɪdz/) are a class of peptides that contain both amino acid and hydroxy acid units. They are formed by a condensation reaction between a carboxyl group of the amino acid and a hydroxyl group of the hydroxy acid.

Etymology

The term "depsipeptide" is derived from the Greek words "depsi", meaning "bond", and "peptide", which refers to the type of chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule.

Structure

Depsipeptides have a unique structure that includes both peptide and ester bonds. The peptide bond is formed between the carboxyl group of an amino acid and the amino group of another. The ester bond, on the other hand, is formed between the carboxyl group of an amino acid and the hydroxyl group of a hydroxy acid.

Types

There are two main types of depsipeptides: linear and cyclic. Linear depsipeptides have a straight chain structure, while cyclic depsipeptides have a ring-like structure.

Biological Activity

Depsipeptides have been found to exhibit a wide range of biological activities, including antibacterial, antifungal, antiviral, and anticancer properties. Some depsipeptides, such as romidepsin and plitidepsin, are currently used in the treatment of certain types of cancer.

Related Terms

• Peptide
• Amino Acid
• Hydroxy Acid
• Condensation Reaction
• Carboxyl Group
• Hydroxyl Group
• Linear Depsipeptides
• Cyclic Depsipeptides
• Romidepsin
• Plitidepsin

External links

• Medical encyclopedia article on Depsipeptides
• Wikipedia's article - Depsipeptides

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