Central pain syndrome

Central pain syndrome
Synonyms	Thalamic pain syndrome, Dejerine–Roussy syndrome
Pronounce	N/A
Specialty	N/A
Symptoms	Chronic pain, burning sensation, allodynia, hyperalgesia
Complications	Depression, anxiety, sleep disturbances
Onset	After stroke, multiple sclerosis, spinal cord injury, or other central nervous system damage
Duration	Long-term
Types	N/A
Causes	Damage to the central nervous system
Risks	Stroke, multiple sclerosis, spinal cord injury, brain tumor
Diagnosis	Clinical diagnosis, MRI
Differential diagnosis	Peripheral neuropathy, fibromyalgia, complex regional pain syndrome
Prevention	N/A
Treatment	Medications, physical therapy, psychotherapy
Medication	Antidepressants, anticonvulsants, opioids
Prognosis	N/A
Frequency	Rare
Deaths	N/A

Central pain syndrome is a neurological condition consisting of constant, moderate to severe pain due to damage to the central nervous system (CNS) which causes a sensitization of the pain system. The extent of pain and the areas affected are related to the cause of the injury.

Signs and symptoms

Pain can either be relegated to a specific part of the body or spread to the entire body. It is typically constant, and may be moderate to severe in intensity. It is often made worse by touch, movement, emotions, barometric pressure and temperature changes, usually cold temperatures along with many other similar 'triggers'. Burning pain is the most common sensation, but patients also report pins and needles, pressing, lacerating, aching, and extreme bursts or constant sharp or unremitting excruciating pain. Individuals may have reduced sensitivity to touch in the areas affected by the pain, as if the part is 'falling asleep'. The burning and loss of sense of touch are usually, but not always, most severe on the distant parts of the body, such as the feet or hands, spreading until it is in some cases felt from head to toe. For some patients with intense affliction, there often can be unremitting nausea, causing vomiting. The pain can also bring on hyperventilation. Blood pressure can rise due to the pain.

Cause

Damage to the CNS can be caused by car accidents, limb amputations, trauma, spinal cord injury, tumors, stroke, immune system disorders or diseases, such as multiple sclerosis, Parkinson's, Graves or Addison's disease, rheumatoid arthritis, and epilepsy.

Diagnosis

A diagnosis of central pain syndrome is based upon identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation and a variety of specialized tests. Central pain syndrome is suspected in individuals who complain of pain or other abnormal sensations following injury to the central nervous system. Other conditions that cause pain may need to be excluded before a diagnosis of central pain syndrome is made.

Treatment

Pain medications often provide some reduction of pain, but not complete relief of pain, for those affected by central pain syndrome. Tricyclic antidepressants such as nortriptyline or anticonvulsants such as neurontin (gabapentin) can be useful, but also provide incomplete relief. Lowering stress levels appears to reduce pain. For regular treatment some people prefer body length heating pads while others rely on warm baths, and most any normal 'hot or cold' help.

Prognosis

Central pain syndrome is not a fatal disorder, but the syndrome causes disabling chronic pain and suffering among the majority of individuals who have it.

See also

• Thalamic syndrome