Cyazofamid
Cyazofamid is a fungicide used in agriculture to control a variety of plant diseases. It belongs to the class of chemicals known as cyanoimidazoles and is particularly effective against oomycete pathogens, which cause diseases such as downy mildew and late blight.
Chemical Properties
Cyazofamid has the chemical formula C13H13ClN4O2S. It is a systemic fungicide, meaning it is absorbed by the plant and distributed throughout its tissues, providing protection from the inside out. The compound works by inhibiting the Qi site of the cytochrome bc1 complex in the mitochondrial electron transport chain, which is essential for the energy production of the pathogen.
Mode of Action
Cyazofamid targets the mitochondrial electron transport chain in oomycetes, specifically inhibiting the Qi site of the cytochrome bc1 complex. This inhibition disrupts the production of ATP, the energy currency of the cell, leading to the death of the pathogen. This mode of action is highly specific to oomycetes, making cyazofamid an effective and selective fungicide.
Uses in Agriculture
Cyazofamid is used to control a variety of diseases caused by oomycetes, including:
- Downy mildew on crops such as grapes, cucumbers, and lettuce.
- Late blight on potatoes and tomatoes.
- Pythium diseases on turf and ornamentals.
It is applied as a foliar spray and is often used in integrated pest management (IPM) programs due to its specificity and low impact on non-target organisms.
Environmental Impact
Cyazofamid is considered to have a low environmental impact. It has a low toxicity to non-target organisms, including mammals, birds, and beneficial insects. However, as with all pesticides, it is important to follow label instructions and use the product responsibly to minimize any potential negative effects on the environment.
Regulation and Safety
Cyazofamid is registered for use in many countries around the world. It is important for users to follow all regulatory guidelines and safety instructions when handling and applying this fungicide. Personal protective equipment (PPE) should be worn to prevent exposure, and care should be taken to avoid contamination of water sources.
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Contributors: Prab R. Tumpati, MD