Voacangine

From WikiMD's medical encyclopedia

Voacangine is an alkaloid found in the Voacanga africana tree, a plant native to Africa. It is a member of the indole alkaloids family, which are known for their complex structures and wide range of biological activities. Voacangine has been studied for its potential medicinal properties, including its use as a precursor in the synthesis of ibogaine, a psychoactive compound used in the treatment of substance abuse disorders.

Chemical Structure and Properties

Voacangine is a monoterpenoid indole alkaloid. Its chemical structure consists of a tryptamine unit, a secologanin unit, and a methoxy group. The compound is a white crystalline solid at room temperature and is soluble in organic solvents such as ethanol and chloroform.

Biological Activity

Voacangine exhibits a variety of biological activities. It has been found to have antimicrobial properties, inhibiting the growth of certain bacteria and fungi. It also shows antioxidant activity, neutralizing harmful free radicals in the body. Furthermore, voacangine has been studied for its potential antitumor effects.

Medical Use

One of the most significant uses of voacangine is its role as a precursor in the synthesis of ibogaine. Ibogaine is a psychoactive compound that has been used in the treatment of substance abuse disorders, particularly opioid addiction. The conversion of voacangine to ibogaine is a complex process that involves several chemical reactions.

Safety and Toxicity

Like many alkaloids, voacangine can be toxic in high doses. Symptoms of voacangine poisoning can include nausea, vomiting, and hallucinations. It is important to use voacangine and other alkaloids responsibly and under the guidance of a healthcare professional.

See Also

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Voacangine

  • Voacangine chemical structure

  • Late-stage voacangine biosynthesis

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Contributors: Prab R. Tumpati, MD