Conoidasida
Conoidasida is a class of parasitic alveolates within the phylum Apicomplexa. Members of this class are characterized by the presence of a conoid, a specialized structure involved in the invasion of host cells. Conoidasida includes several important parasites that affect both humans and animals.
Taxonomy
The class Conoidasida is divided into two main subclasses:
Coccidia
Coccidia are intracellular parasites that primarily infect the intestinal tracts of animals. Notable genera within this subclass include:
Eimeria
Eimeria species are known to cause coccidiosis in livestock, leading to significant economic losses in the agricultural industry.
Isospora
Isospora species are primarily known for causing isosporiasis in humans and animals, particularly in immunocompromised individuals.
Toxoplasma
Toxoplasma gondii is the causative agent of toxoplasmosis, a disease that can have severe consequences for pregnant women and immunocompromised individuals.
Gregarinia
Gregarinia are parasites that primarily infect the intestines of invertebrates, particularly arthropods and annelids. They are less studied compared to Coccidia but are important for understanding the diversity and evolution of parasitic alveolates.
Morphology
Members of Conoidasida possess a conoid, a cone-shaped structure composed of microtubules. This structure is part of the apical complex, which also includes rhoptries, micronemes, and dense granules. The apical complex is essential for the invasion of host cells.
Life Cycle
The life cycle of Conoidasida typically involves both sexual and asexual reproduction. The asexual phase often includes multiple rounds of schizogony, leading to the production of numerous merozoites. The sexual phase involves the formation of gametes and the production of oocysts, which are then transmitted to new hosts.
Pathogenesis
Conoidasida parasites are responsible for a variety of diseases in humans and animals. These diseases can range from mild gastrointestinal disturbances to severe, life-threatening conditions. The pathogenicity of these parasites is often related to their ability to invade and destroy host cells.
Diagnosis and Treatment
Diagnosis of infections caused by Conoidasida typically involves microscopic examination of stool samples, serological tests, and molecular methods such as PCR. Treatment options vary depending on the specific parasite but may include antiparasitic medications such as sulfadiazine and pyrimethamine.
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Contributors: Prab R. Tumpati, MD