Clonus

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Obesity, Sleep & Internal medicine
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Clonus
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Involuntary, rhythmic muscle contractions
Complications	N/A
Onset	Sudden
Duration	Variable
Types	N/A
Causes	Upper motor neuron lesion, multiple sclerosis, stroke, spinal cord injury
Risks	Neurological disorders
Diagnosis	Physical examination, neurological examination
Differential diagnosis	Myoclonus, tremor, seizure
Prevention	N/A
Treatment	Physical therapy, medication
Medication	Baclofen, benzodiazepines
Prognosis	Depends on underlying cause
Frequency	Common in certain neurological conditions
Deaths	N/A

Clonus

Clonus is a neurological condition characterized by involuntary, rhythmic muscle contractions and relaxations in rapid succession. This form of movement disorder is often a sign of a neurological problem and can be indicative of damage to the nerve tracts, particularly those that descend from the upper motor neuron in the central nervous system to the muscle. Clonus is most commonly observed in the ankles, wrists, and knees and is frequently tested for during neurological examinations as part of reflex testing.

Introduction

Clonus can be an indication of several neurological conditions, suggesting an injury to the upper motor neuron pathways. It is often associated with conditions such as multiple sclerosis, stroke, spinal cord injury, and cerebral palsy. The presence and severity of clonus can help in diagnosing and determining the extent of neurological damage.

A doctor performing a neurological examination to test for clonus.

Characteristics

Clonus is characterized by involuntary and rhythmic muscle contractions that are caused by a sudden stretching of the muscle, leading to a series of quick, jerky movements. These contractions can continue until the muscle is relaxed or until the stretching force is removed. The rapid contraction and relaxation cycle can vary in frequency and duration depending on the severity of the neurological impairment.

Causes

The primary cause of clonus is damage to the nerve tracts that convey signals from the brain to the muscles. This damage disrupts the normal inhibition that the brain exerts on muscle tone and reflexes, leading to hyperactive responses such as clonus. Conditions that can lead to clonus include:

• Stroke
• Multiple sclerosis
• Spinal cord injury
• Cerebral palsy
• Severe head injury

Diagnostic Importance

Clonus is a significant indicator of neurological dysfunction and is particularly useful in diagnosing upper motor neuron lesions. During reflex testing, the ability to elicit clonus, especially sustained clonus, suggests damage to the nerve tracts above the point at which the reflex is initiated. Neurologists assess the presence and severity of clonus as part of a comprehensive neurological examination to evaluate the extent of neurological damage and to aid in the diagnosis of underlying conditions.

Treatment Options

While there is no cure for clonus itself, treatment focuses on managing the underlying condition and relieving the symptoms. Options may include:

• Physical therapy to improve muscle control and reduce spasms
• Medications such as muscle relaxants or antispasmodics to decrease muscle hyperactivity
• Use of orthotic devices to stabilize and support affected limbs
• In severe cases, surgical interventions to address nerve or muscle dysfunction

See Also

• Neurology
• Upper motor neuron
• Muscle contraction
• Reflexes

External Links

• National Institute of Neurological Disorders and Stroke - Spasticity Fact Sheet
• National Center for Biotechnology Information - Clonus

References

• "Clonus: Pathophysiology and Treatment." Journal of Neurology & Neuromedicine.
• "The Diagnostic Value of Clonus in Neurological Disorders." Archives of Physical Medicine and Rehabilitation.

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