Casopitant

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Casopitant (pronounced as ka-SO-pi-tant) is a drug that is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is a member of the drug class known as neurokinin 1 (NK1) receptor antagonists.

Etymology

The term Casopitant is derived from the Latin word casus, meaning fall or accident, and pitan, a term used in pharmacology to denote a substance that blocks or inhibits a biological action. Thus, Casopitant can be interpreted as a substance that blocks or inhibits the action of the NK1 receptor, which is involved in the induction of nausea and vomiting.

Pharmacology

Casopitant is a highly selective and potent antagonist of the human substance P/neurokinin 1 (NK1) receptor. It works by blocking the action of substance P, a neurotransmitter in the brain that plays a key role in the vomiting reflex. By blocking the action of substance P, casopitant can prevent and treat nausea and vomiting caused by chemotherapy.

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