Calciphylaxis

Calciphylaxis ; ;
Synonyms	Calcific uremic arteriolopathy ;
Specialty	Nephrology, Dermatology
Symptoms	Painful skin ulcers, necrosis
Complications	Sepsis, organ failure ; ; ;
Causes	Chronic kidney disease, hyperparathyroidism, diabetes mellitus
Risk factors	End-stage renal disease, obesity, female gender
Diagnosis	Skin biopsy, clinical evaluation
Differential diagnosis	Warfarin-induced skin necrosis, cholesterol embolism ;
Treatment	Sodium thiosulfate, wound care, pain management ;
Prognosis	Poor
Frequency	Rare ;

Rare and serious disease characterized by calcification of blood vessels

Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare and serious disease characterized by the calcification of small blood vessels within the dermis and subcutaneous tissue. This condition leads to the development of painful skin ulcers and can result in necrosis.

Symptoms[edit]

The primary symptoms of calciphylaxis include:

Painful skin ulcers
Areas of necrosis
Erythema and induration around the affected areas

Complications[edit]

Calciphylaxis can lead to severe complications such as:

Causes[edit]

The exact cause of calciphylaxis is not fully understood, but it is commonly associated with:

Risk Factors[edit]

Several risk factors have been identified for calciphylaxis, including:

Diagnosis[edit]

Diagnosis of calciphylaxis is typically made through:

Clinical evaluation
Skin biopsy

Differential Diagnosis[edit]

Conditions that may present similarly and should be considered include:

Treatment[edit]

Treatment options for calciphylaxis focus on managing symptoms and may include:

Prognosis[edit]

The prognosis for calciphylaxis is generally poor, with a high risk of mortality due to complications such as sepsis and organ failure.

References[edit]

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Calciphylaxis
Synonyms	Calcific uremic arteriolopathy
Specialty	Nephrology, Dermatology
Symptoms	Painful skin ulcers, necrosis
Complications	Sepsis, organ failure
Causes	Chronic kidney disease, hyperparathyroidism, diabetes mellitus
Risk factors	End-stage renal disease, obesity, female gender
Diagnosis	Skin biopsy, clinical evaluation
Differential diagnosis	Warfarin-induced skin necrosis, cholesterol embolism
Treatment	Sodium thiosulfate, wound care, pain management
Prognosis	Poor
Frequency	Rare