CSDA (gene)
CSDA is a gene that in humans is encoded by the CSDA gene. It is also known as Cold Shock Domain Protein A. This gene is located on chromosome 1 (1p34.2) and spans approximately 13.5 kilobases. The CSDA gene produces a protein that is involved in the regulation of cell growth and cell differentiation.
Function
The CSDA gene encodes a protein that belongs to the Y-box binding protein family. This protein is a DNA- and RNA-binding protein and is involved in various cellular processes, including transcription and translation, DNA repair, cell proliferation, and apoptosis. It is also involved in the regulation of the cell cycle and has been implicated in several human cancers.
Structure
The CSDA protein is composed of 306 amino acids and has a molecular weight of approximately 34 kDa. It contains a cold shock domain (CSD), which is a nucleic acid-binding domain that is found in a variety of proteins involved in cellular processes such as transcription, translation, and DNA repair.
Clinical Significance
Alterations in the CSDA gene have been associated with several types of cancer, including breast cancer, lung cancer, and colorectal cancer. In addition, mutations in the CSDA gene have been linked to neurodevelopmental disorders.
Research
Research is ongoing to further understand the role of the CSDA gene in human health and disease. This includes studies to determine the specific mechanisms by which alterations in the CSDA gene contribute to the development of cancer and neurodevelopmental disorders.
See Also
- Gene
 - Chromosome 1
 - Cell growth
 - Cell differentiation
 - Transcription (genetics)
 - Translation (biology)
 - DNA repair
 - Cell proliferation
 - Apoptosis
 - Breast cancer
 - Lung cancer
 - Colorectal cancer
 - Neurodevelopmental disorder
 
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Contributors: Prab R. Tumpati, MD