CFU-Meg

CFU-Meg or Colony-forming unit-megakaryocyte is a type of stem cell that produces megakaryocytes, which are large cells found in the bone marrow that later develop into platelets, a type of blood cell essential for normal blood clotting.

Overview

CFU-Meg is a type of colony-forming unit (CFU), a term used in hematology to describe a cell that can proliferate and differentiate into a colony of more mature cells. In the case of CFU-Meg, these are megakaryocytes.

Function

The primary function of CFU-Meg is to produce megakaryocytes. These cells are responsible for the production of platelets, which play a crucial role in blood clotting. When an injury occurs and a blood vessel is damaged, platelets gather at the site of the injury and form a clot to prevent excessive bleeding.

Clinical significance

Abnormalities in CFU-Meg can lead to various medical conditions. For instance, a decrease in the number of CFU-Meg can result in thrombocytopenia, a condition characterized by low platelet count. On the other hand, an increase in the number of CFU-Meg can lead to thrombocytosis, a condition characterized by an excessive number of platelets.

See also

• Hematopoietic stem cell
• Colony-forming unit
• Megakaryocyte
• Platelet

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