CDH11

CDH11 or Cadherin-11 is a protein that in humans is encoded by the CDH11 gene. Cadherins are calcium-dependent cell-cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH11 is a type II classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in osteoblasts and plays an important role in bone development. The protein may be associated with bone deterioration in postmenopausal women and in rheumatoid arthritis.

Function

Cadherin-11 is a type II classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This protein functions in osteoblasts and is thought to play a crucial role in osteoblast differentiation and osteogenesis.

Clinical significance

CDH11 has been associated with rheumatoid arthritis and osteoarthritis. It is also associated with bone deterioration in postmenopausal women. In addition, it has been implicated in certain types of cancer, including breast cancer and prostate cancer.

See also

• Cadherin
• Osteoblast
• Rheumatoid arthritis
• Osteoarthritis
• Breast cancer
• Prostate cancer

External links

• CDH11 at the National Center for Biotechnology Information

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