CDH10

CDH10 is a gene that in humans encodes the protein Cadherin 10, a type II classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is believed to play a crucial role in the establishment and function of specific cell-cell connections in the brain.

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH10 is thought to play a role in the establishment and function of specific cell-cell connections in the brain.

Clinical significance

Mutations in the CDH10 gene have been associated with autism spectrum disorder.

See also

• Cadherin
• Autism spectrum

External links

• CDH10 at the National Center for Biotechnology Information

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