Bucolome
Bucolome is a pharmacological agent that is primarily used in the treatment of gout and hyperuricemia. It is classified as a uricosuric agent, which means it increases the excretion of uric acid in the urine, thereby reducing the concentration of uric acid in the body. Bucolome was first synthesized in the 1960s and has been used in Japan and other Asian countries for several decades.
Pharmacology
Bucolome works by inhibiting the reabsorption of uric acid in the kidney's tubules, which leads to an increase in the excretion of uric acid. This reduces the concentration of uric acid in the body, which can help to prevent the formation of uric acid crystals that cause gout.
Bucolome is metabolized in the liver and excreted in the urine. It has a half-life of approximately 12 hours, which means that it is eliminated from the body relatively slowly. This allows for once or twice daily dosing.
Clinical Use
Bucolome is used in the treatment of gout and hyperuricemia. It is particularly useful in patients who have high levels of uric acid in their blood, despite dietary modifications and other treatments. Bucolome can be used alone or in combination with other gout medications, such as allopurinol or febuxostat.
Side Effects
Like all medications, Bucolome can cause side effects. The most common side effects are gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Less commonly, Bucolome can cause rash, dizziness, and headache. Rarely, it can cause more serious side effects, such as liver damage or kidney damage.
Contraindications
Bucolome is contraindicated in patients with severe kidney or liver disease, as these conditions can affect the metabolism and excretion of the drug. It is also contraindicated in patients who are allergic to Bucolome or any of its components.
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Contributors: Prab R. Tumpati, MD
