Bruce Beutler
Bruce Beutler (pronounced: broos byoot-lur) is an American immunologist and geneticist. He was born on December 29, 1957, in Chicago, Illinois. Beutler is best known for his work in identifying the Toll-like receptors (TLRs) and their role in the innate immune system, which earned him the Nobel Prize in Physiology or Medicine in 2011.
Early Life and Education
Bruce Beutler was born to a family of Jewish descent. His father, Ernest Beutler, was a renowned hematologist and geneticist. Beutler completed his high school education at Polytechnic School in Pasadena, California. He then pursued his undergraduate studies at the University of California, San Diego, where he received a Bachelor of Science degree in Biology in 1976. He earned his M.D. from the University of Chicago in 1981.
Career
After completing his medical degree, Beutler joined the Scripps Research Institute in La Jolla, California, where he began his research on the innate immune system. His most significant discovery came in 1998 when he identified the Toll-like receptor 4 (TLR4) as a key receptor for lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria. This discovery revolutionized our understanding of how the body recognizes and responds to microbial infections.
In 2000, Beutler moved to the University of Texas Southwestern Medical Center in Dallas, where he continued his research on TLRs and the innate immune system. In 2011, he shared the Nobel Prize in Physiology or Medicine with Jules A. Hoffmann and Ralph M. Steinman for their discoveries concerning the activation of innate immunity.
Personal Life
Beutler is married and has two children. He is an avid reader and enjoys playing the piano in his spare time.
See Also
External links
- Medical encyclopedia article on Bruce Beutler
- Wikipedia's article - Bruce Beutler
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