Brain mitochondrial carrier protein 1

Brain Mitochondrial Carrier Protein 1 (BMCP1) is a protein that in humans is encoded by the SLC25A14 gene. This protein is a member of the mitochondrial carrier family, which is involved in the exchange of metabolites across the mitochondrial inner membrane.

Function

BMCP1 is a neuron-specific member of the mitochondrial carrier family. It is expressed predominantly in the brain, with the highest levels found in the cerebellum. The protein is localized to the mitochondria, where it may function in the transport of metabolites.

Structure

The SLC25A14 gene encoding BMCP1 is located on chromosome 3 (3q21.3). The protein is composed of 338 amino acids and has a molecular weight of approximately 37 kDa. Like other members of the mitochondrial carrier family, BMCP1 is predicted to have six transmembrane domains, forming a barrel-like structure in the mitochondrial inner membrane.

Clinical significance

Alterations in the expression of BMCP1 have been associated with various neurological disorders, including schizophrenia and bipolar disorder. However, the exact role of this protein in the pathogenesis of these disorders remains unclear.

Research

Research into the function and potential clinical significance of BMCP1 is ongoing. Current studies are focused on elucidating the specific metabolites transported by this protein and understanding its role in neuronal function and disease.

See also

• Mitochondrial carrier
• SLC25A14
• Mitochondria
• Neuron

References

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Brain_mitochondrial_carrier_protein_1

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  UCP1 in the cell

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  Mitochondrial Uncoupling Protein 2