Bone marrow-derived macrophage

Bone Marrow-Derived Macrophage

Diagram of BMDM production

Bone marrow-derived macrophages (BMDMs) are a type of macrophage that are generated from hematopoietic stem cells in the bone marrow. These cells play a crucial role in the immune system, acting as phagocytes that engulf and digest cellular debris, foreign substances, and pathogens. BMDMs are widely used in research to study macrophage biology and the immune response.

Development

BMDMs are derived from monocytes, which are a type of white blood cell that circulates in the bloodstream. Monocytes originate from hematopoietic stem cells in the bone marrow and differentiate into macrophages when they migrate into tissues. The process of differentiation involves several stages, including the development of progenitor cells and precursor cells before becoming mature macrophages.

Function

Macrophages, including BMDMs, are essential components of the innate immune system. They are involved in the detection, phagocytosis, and destruction of bacteria and other harmful organisms. Macrophages also play a role in antigen presentation, where they process and present antigens to T cells, thus linking the innate and adaptive immune responses.

Research Applications

BMDMs are commonly used in laboratory research to study various aspects of macrophage function, including their role in inflammation, tissue repair, and immune response. They are also used to investigate the effects of different cytokines and growth factors on macrophage behavior. The ability to culture BMDMs in vitro provides a valuable tool for studying the molecular mechanisms underlying macrophage activity.

Related Pages

• Macrophage
• Hematopoietic stem cell
• Immune system
• Phagocytosis
• Antigen presentation