Bistratified cell

Bistratified cell is a type of neuron found in the retina of the eye. These cells are part of the retinal ganglion cell population and play a crucial role in visual processing. Bistratified cells are named for their dendritic stratification in two distinct layers of the inner plexiform layer (IPL), which allows them to receive input from both ON and OFF bipolar cells.

Anatomy

Bistratified cells are characterized by their dendrites branching into two distinct layers of the IPL. The upper (proximal) layer of dendrites receives input from OFF bipolar cells, which are activated by a decrease in light intensity. The lower (distal) layer receives input from ON bipolar cells, which are activated by an increase in light intensity. This unique anatomical feature allows bistratified cells to process both ON and OFF signals simultaneously.

Function

The primary function of bistratified cells is to contribute to the processing of color and motion in the visual system. They are part of the parvocellular pathway, which is responsible for processing fine detail and color information. Bistratified cells are also involved in the magnocellular pathway, which processes motion information.

Bistratified cells are thought to play a role in the perception of the blue-yellow color axis. They receive input from short-wavelength sensitive (S) cone cells and from a combination of medium- and long-wavelength sensitive (M and L) cone cells, allowing them to compare the signals from these different types of cones and contribute to color discrimination.

Clinical significance

Changes in the function or number of bistratified cells can lead to visual impairments. For example, glaucoma, a disease characterized by damage to the retinal ganglion cells, can affect bistratified cells and result in loss of color and motion perception. Research into the role of bistratified cells in visual processing and disease is ongoing.

See also

• Retina
• Retinal ganglion cell
• Bipolar cell
• Parvocellular pathway
• Magnocellular pathway

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