Biological specimen
Biological specimen refers to any biological material collected from living or dead organisms, or from the environment, that is used for the purpose of analysis, research, or as a reference in biological studies. These specimens can include blood, saliva, tissues, cells, DNA, as well as larger parts like organs, limbs, or even entire organisms. Biological specimens play a crucial role in various fields such as medicine, biology, forensic science, and environmental science, providing essential data for diagnosis, research, and understanding of life and its processes.
Collection and Preservation
The collection and preservation of biological specimens are critical steps that ensure the integrity and reliability of the data obtained from them. The methods of collection and preservation vary widely depending on the type of specimen and the intended analysis. For instance, blood samples are usually collected using sterile techniques and may be preserved with anticoagulants to prevent clotting. Tissue samples for histological examination are often fixed in formalin to preserve their structure. Environmental samples, such as soil or water, may be collected using special containers to avoid contamination and are often preserved by refrigeration or freezing.
Types of Biological Specimens
Biological specimens can be broadly categorized into several types based on their origin and nature:
- Human specimens: Include samples like blood, urine, tissues, and cells collected for medical testing, research, or transplantation.
 - Animal specimens: Collected from animals for research in veterinary medicine, comparative biology, or for conservation efforts.
 - Plant specimens: Include parts of plants or whole plants collected for botanical research, conservation, and study of plant diseases.
 - Microbial specimens: Consist of bacteria, viruses, fungi, and other microorganisms collected for research in microbiology, infectious diseases, and biotechnology.
 - Environmental specimens: Include samples of air, water, soil, and sediments collected for environmental monitoring, pollution assessment, and ecological studies.
 
Ethical Considerations
The collection and use of biological specimens, especially human specimens, are subject to ethical considerations. Informed consent from donors, confidentiality of donor information, and the ethical use of specimens for research are paramount. Ethical guidelines and regulations, such as the Declaration of Helsinki and the Common Rule, provide frameworks for the ethical collection, use, and storage of biological specimens.
Storage and Database
Proper storage of biological specimens is essential to maintain their integrity and utility for future analysis. Specimens may be stored at room temperature, refrigerated, or frozen, depending on their nature and the duration of storage. Biobanks and biorepositories play a crucial role in the storage and management of biological specimens, offering a valuable resource for medical and scientific research.
Biological specimen databases are digital platforms that catalog and manage information related to the specimens, including their origin, type, collection data, and analysis results. These databases facilitate the sharing of specimens and data among researchers, enhancing collaboration and advancing scientific knowledge.
Conclusion
Biological specimens are invaluable resources for scientific research and medical diagnosis. Their collection, preservation, and ethical use are fundamental to advancing our understanding of the natural world and improving human health. As technology and science progress, the importance of biological specimens in research and medicine continues to grow, highlighting the need for continued ethical consideration, proper management, and innovative techniques in specimen collection and preservation.
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Contributors: Prab R. Tumpati, MD