Biobreeding rat
Biobreeding rat
Biobreeding rat (pronunciation: bio-breeding rat) is a type of laboratory rat that is genetically predisposed to develop insulin-dependent diabetes mellitus, also known as Type 1 diabetes.
Etymology
The term "biobreeding" is derived from the process of selectively breeding these rats to develop diabetes for research purposes. The term "rat" is from Old English ræt, of unknown origin.
Description
Biobreeding rats are used as an animal model in diabetes research. They spontaneously develop autoimmune diabetes, which closely resembles human Type 1 diabetes. The onset of diabetes in these rats is preceded by insulitis, a condition characterized by the infiltration of lymphocytes into the islets of Langerhans in the pancreas.
Genetics
The genetic predisposition of biobreeding rats to diabetes is linked to the Major Histocompatibility Complex (MHC), specifically the RT1 region. The RT1u haplotype is associated with susceptibility to diabetes, while the RT1a haplotype is associated with resistance.
Related Terms
- Insulin-dependent diabetes mellitus
- Type 1 diabetes
- Lymphocytes
- Islets of Langerhans
- Major Histocompatibility Complex
- RT1 region
External links
- Medical encyclopedia article on Biobreeding rat
- Wikipedia's article - Biobreeding rat
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