Bafilomycin

Bafilomycin is a type of macrolide antibiotic that is derived from Streptomyces griseus. It is known for its ability to inhibit V-ATPase, a type of ATPase that is found in the membranes of many types of cells.

History

Bafilomycin was first isolated in 1983 from a strain of Streptomyces griseus. It was found to have potent antifungal activity, and later research revealed its ability to inhibit V-ATPase.

Structure and properties

Bafilomycin is a macrolide antibiotic, which means it has a large macrocyclic lactone ring. It also contains a sugar moiety and a polyketide moiety. The structure of bafilomycin is complex and contains several stereocenters, which makes it difficult to synthesize in the lab.

Mechanism of action

Bafilomycin works by inhibiting V-ATPase, a type of ATPase that is found in the membranes of many types of cells. V-ATPase is responsible for acidifying certain parts of the cell, such as the lysosome and the Golgi apparatus. By inhibiting V-ATPase, bafilomycin disrupts the normal functioning of these organelles.

Uses

Bafilomycin has been used in research to study the role of V-ATPase in various cellular processes. It has also been used to study the effects of pH on the function of certain proteins. In addition, bafilomycin has potential therapeutic uses. For example, it has been shown to have antifungal activity, and it may also have potential as a treatment for cancer and neurodegenerative diseases.

See also

• Macrolide
• V-ATPase
• Streptomyces griseus

References

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