Armitage–Doll multistage model of carcinogenesis

The Armitage–Doll model is a statistical model of carcinogenesis, proposed in 1954 by Peter Armitage and Richard Doll, which suggested that a sequence of multiple distinct genetic events preceded the onset of cancer. The original paper has recently been reprinted with a set of commentary articles.

References

• Armitage, P. and Doll, R. (1954) "The Age Distribution of Cancer and a Multi-Stage Theory Of Carcinogenesis", British Journ. of Cancer, 8 (1), 1-12. Reprinted (2004): reprint, British Journal of Cancer, 91, 1983–1989. doi:10.1038/sj.bjc.6602297

• P Armitage and R Doll (2004) "The age distribution of cancer and a multi-stage theory of carcinogenosis", Int. J. Epidemiol 33(6): 1174-1179 doi:10.1093/ije/dyh216

• Steven A Frank (2004) "Commentary: Mathematical models of cancer progression and epidemiology in the age of high throughput genomics", Int. J. Epidemiol. 33(6): 1179-1181 doi:10.1093/ije/dyh222

• Suresh H Moolgavkar (2004) "Commentary: Fifty years of the multistage model: remarks on a landmark paper", Int. J. Epidemiol. 33(6): 1182-1183 doi:10.1093/ije/dyh288

• Richard Doll (2004) "Commentary: The age distribution of cancer and a multistage theory of carcinogenesis", Int. J. Epidemiol. 33(6): 1183-1184 doi:10.1093/ije/dyh359