Armine (chemical)

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Armine

Chemical structure of Armine

Armine is a chemical compound that belongs to the class of organophosphates. It is primarily known for its use as a pesticide and has been studied for its effects on the nervous system.

Chemical Structure

The chemical structure of Armine is characterized by the presence of a phosphorus atom bonded to an oxygen atom and two alkyl groups. This structure is typical of many organophosphates, which are known for their ability to inhibit acetylcholinesterase, an important enzyme in the nervous system.

Mechanism of Action

Armine functions by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine in the synaptic cleft. By inhibiting this enzyme, Armine causes an accumulation of acetylcholine, leading to continuous stimulation of muscles, glands, and central nervous system neurons. This can result in symptoms such as muscle twitching, respiratory distress, and, in severe cases, death.

Uses

Armine has been used in agriculture as a pesticide due to its effectiveness in controlling insect populations. However, due to its potential toxicity to humans and other non-target organisms, its use is highly regulated in many countries.

Toxicity and Safety

Exposure to Armine can occur through inhalation, ingestion, or skin contact. Symptoms of exposure include headache, dizziness, nausea, and convulsions. In cases of severe poisoning, antidotes such as atropine and pralidoxime are used to counteract the effects of acetylcholinesterase inhibition.

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Contributors: Prab R. Tumpati, MD