Antimycin A
Antimycin A
Antimycin A (/æntɪˈmaɪsɪn eɪ/) is a secondary metabolite produced by the bacterium Streptomyces. It is a member of the antimycin complex and is known for its role as a potent inhibitor of the electron transport chain in mitochondria.
Etymology
The term "Antimycin A" is derived from the genus name of the bacterium that produces it, Streptomyces, and the letter "A" to denote its position in the antimycin complex.
Pharmacology
Antimycin A inhibits the electron transport chain by binding to the cytochrome c reductase, specifically the Qi site, preventing the transfer of electrons from cytochrome c1 to cytochrome c. This inhibition results in the cessation of oxidative phosphorylation, leading to a decrease in ATP production.
Medical Uses
Antimycin A has been used in research as a tool to study the electron transport chain and oxidative phosphorylation. It has also been used in the treatment of parasitic infections in fish.
Related Compounds
Other members of the antimycin complex include Antimycin B, Antimycin C, and Antimycin D. These compounds have similar structures and mechanisms of action but differ in their specificities and potencies.
See Also
External links
- Medical encyclopedia article on Antimycin A
- Wikipedia's article - Antimycin A
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