Angiomyofibroblastoma

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Angiomyofibroblastoma is an uncommon benign mesenchymal tumor. It occurs almost in the vulvovaginal area of women, but can also be observed in men.

The gross features of AMFB are well-circumscribed. Usually, most tumors grow slowly, and patients do not feel pain. It also has low tendency for local recurrence.

Location

In women
- Female genital tract^[1]
- Vulva^[2]
- Posterior perivesical space^[3]
In men
- Spermatic cord^[4]

Pathology

Microscopical examination shows abundant thin-walled blood vessels with hypocellular and hypercellular areas.

Immunohistochemistry

Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also express estrogen receptors and/or progesterone receptors, but staining for cytokeratin is negative.^[5]

References

↑ , Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract, Chinese Medical Journal, 2000, Vol. 113(Issue: 11), pp. 1036–9, PMID: 11776120,
↑ , Angiomyofibroblastoma of the vulva, Obstetrics & Gynecology Science, 2013, Vol. 56(Issue: 5), pp. 349–51, DOI: 10.5468/ogs.2013.56.5.349, PMID: 24328028, PMC: 3784123,
↑ , Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings, Korean Journal of Radiology, 2008, Vol. 9(Issue: 4), pp. 382–5, DOI: 10.3348/kjr.2008.9.4.382, PMID: 18682679, PMC: 2627271,
↑ , Angiomyofibroblastoma of the spermatic cord: A case report, Journal of Medical Case Reports, 2010, Vol. 4, pp. 79, DOI: 10.1186/1752-1947-4-79, PMID: 20202207, PMC: 2838917,
↑ , Angiomyofibroblastoma of the vulva, Obstetrics & Gynecology Science, 2013, Vol. 56(Issue: 5), pp. 349–51, DOI: 10.5468/ogs.2013.56.5.349, PMID: 24328028, PMC: 3784123,

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[1] , Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract, Chinese Medical Journal, 2000, Vol. 113(Issue: 11), pp. 1036–9, PMID: 11776120,

[2] , Angiomyofibroblastoma of the vulva, Obstetrics & Gynecology Science, 2013, Vol. 56(Issue: 5), pp. 349–51, DOI: 10.5468/ogs.2013.56.5.349, PMID: 24328028, PMC: 3784123,

[3] , Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings, Korean Journal of Radiology, 2008, Vol. 9(Issue: 4), pp. 382–5, DOI: 10.3348/kjr.2008.9.4.382, PMID: 18682679, PMC: 2627271,

[4] , Angiomyofibroblastoma of the spermatic cord: A case report, Journal of Medical Case Reports, 2010, Vol. 4, pp. 79, DOI: 10.1186/1752-1947-4-79, PMID: 20202207, PMC: 2838917,

[5] , Angiomyofibroblastoma of the vulva, Obstetrics & Gynecology Science, 2013, Vol. 56(Issue: 5), pp. 349–51, DOI: 10.5468/ogs.2013.56.5.349, PMID: 24328028, PMC: 3784123,

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