Angiomyofibroblastoma

Angiomyofibroblastoma is an uncommon benign mesenchymal tumor. It occurs almost in the vulvovaginal area of women, but can also be observed in men.

The gross features of AMFB are well-circumscribed. Usually, most tumors grow slowly, and patients do not feel pain. It also has low tendency for local recurrence.

Location

• In women
  • Female genital tract<ref>,

 Clinicopathologic analysis of angiomyofibroblastoma of the female genital tract, 
 Chinese Medical Journal, 
 2000,
 Vol. 113(Issue: 11),
 pp. 1036–9,
 
 PMID: 11776120,</ref> 

• • Vulva<ref>,

 Angiomyofibroblastoma of the vulva, 
 Obstetrics & Gynecology Science, 
 2013,
 Vol. 56(Issue: 5),
 pp. 349–51,
 DOI: 10.5468/ogs.2013.56.5.349,
 PMID: 24328028,
 PMC: 3784123,</ref>

• • Posterior perivesical space<ref>,

 Angiomyofibroblastoma arising from the posterior perivesical space: A case report with MR findings, 
 Korean Journal of Radiology, 
 2008,
 Vol. 9(Issue: 4),
 pp. 382–5,
 DOI: 10.3348/kjr.2008.9.4.382,
 PMID: 18682679,
 PMC: 2627271,</ref>

• In men
  • Spermatic cord<ref>,

 Angiomyofibroblastoma of the spermatic cord: A case report, 
 Journal of Medical Case Reports, 
 2010,
 Vol. 4,
 pp. 79,
 DOI: 10.1186/1752-1947-4-79,
 PMID: 20202207,
 PMC: 2838917,</ref>

Pathology

Microscopical examination shows abundant thin-walled blood vessels with hypocellular and hypercellular areas.

Immunohistochemistry

Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also express estrogen receptors and/or progesterone receptors, but staining for cytokeratin is negative.<ref>,

 Angiomyofibroblastoma of the vulva, 
 Obstetrics & Gynecology Science, 
 2013,
 Vol. 56(Issue: 5),
 pp. 349–51,
 DOI: 10.5468/ogs.2013.56.5.349,
 PMID: 24328028,
 PMC: 3784123,</ref>