Alternating electric field therapy

Alternating Electric Field Therapy

Septins and TTFields

Alternating electric field therapy, also known as tumor treating fields (TTFields), is a novel cancer treatment modality that utilizes low-intensity, intermediate frequency electric fields to disrupt cancer cell division. This therapy is primarily used in the treatment of glioblastoma and other types of cancer.

Mechanism of Action

Alternating electric field therapy works by applying electric fields to the tumor site using transducer arrays placed on the skin. These electric fields are tuned to specific frequencies that interfere with the mitotic process of cancer cells. The electric fields exert forces on charged and polarizable molecules within the cells, leading to disruption of the mitotic spindle and other critical structures during cell division.

The therapy specifically targets rapidly dividing cells, which are characteristic of cancerous tissues, while sparing normal, non-dividing cells. This selectivity is due to the fact that dividing cells have a higher electrical conductivity and are more susceptible to the effects of the electric fields.

Clinical Applications

Dielectrophoresis from TTFields

Alternating electric field therapy is primarily used in the treatment of glioblastoma multiforme, a highly aggressive form of brain cancer. It is often used in conjunction with other treatments such as surgery, radiation therapy, and chemotherapy.

The therapy has also been explored for use in other types of cancer, including non-small cell lung cancer, pancreatic cancer, and ovarian cancer. Clinical trials are ongoing to determine the efficacy and safety of TTFields in these and other cancer types.

Advantages and Limitations

One of the main advantages of alternating electric field therapy is its non-invasive nature. The treatment is delivered through external arrays, eliminating the need for surgical intervention. Additionally, TTFields have been shown to have minimal systemic side effects compared to traditional cancer therapies.

However, the therapy does have limitations. The placement of transducer arrays can be cumbersome and may cause skin irritation. Furthermore, the effectiveness of TTFields can vary depending on the type and location of the tumor.

Future Directions

Research is ongoing to optimize the parameters of alternating electric field therapy, such as frequency and intensity, to improve its efficacy. There is also interest in combining TTFields with other emerging therapies, such as immunotherapy, to enhance treatment outcomes.

Related Pages

• Glioblastoma
• Cancer treatment
• Radiation therapy
• Chemotherapy