Almorexant
Almorexant (pronounced: al-mor-ex-ant) is a type of medication that was developed for the treatment of insomnia. It is classified as an orexin receptor antagonist, which means it works by blocking the action of a hormone called orexin that regulates wakefulness.
Etymology
The name "Almorexant" is derived from the Latin words "almus" meaning nourishing and "rex" meaning king. This could possibly refer to the drug's potential to provide restful sleep, which is nourishing to the body.
Pharmacology
Almorexant acts by inhibiting the binding of orexin to its receptors, thus reducing the wake-promoting effects of orexin. This results in the promotion of sleep. It is a dual orexin receptor antagonist (DORA), meaning it blocks both Orexin receptor type 1 (OX1) and type 2 (OX2).
Clinical Trials
Almorexant was developed by Actelion and GlaxoSmithKline and underwent Phase III clinical trials. However, the development was discontinued in 2011 due to concerns about its side effects.
Side Effects
The most common side effects of Almorexant include dizziness, nausea, and fatigue. In some cases, it may also cause abnormal dreams and dry mouth.
Related Terms
External links
- Medical encyclopedia article on Almorexant
- Wikipedia's article - Almorexant
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