Allethrins
Allethrins
Allethrins are a group of synthetic compounds used as insecticides. They belong to the class of pyrethroids, which are synthetic analogs of the naturally occurring insecticidal compounds known as pyrethrins. Allethrins are commonly used in household insecticides, such as mosquito coils and sprays, due to their effectiveness in killing insects and their relatively low toxicity to humans and animals.
Chemical Structure
Allethrins are characterized by their complex chemical structure, which includes a cyclopropane carboxylate ester linked to a chrysanthemic acid moiety. The general formula for allethrins is C19H26O3. The structure of allethrin can be modified to produce different variants, such as d-allethrin and esbiothrin, which have varying levels of potency and stability.
Mechanism of Action
Allethrins work by targeting the nervous system of insects. They act on the sodium channels in the nerve cells, causing prolonged opening of these channels. This results in continuous nerve impulses, leading to paralysis and death of the insect. The specificity of allethrins for insect sodium channels over those of mammals contributes to their safety profile.
Uses
Allethrins are widely used in various insect control products. They are effective against a broad range of insects, including mosquitoes, flies, and cockroaches. Common applications include:
Safety and Environmental Impact
While allethrins are considered to have low toxicity to humans and pets, they can be harmful to aquatic life and should be used with caution near water bodies. Proper handling and adherence to usage instructions are important to minimize any potential risks.
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Contributors: Prab R. Tumpati, MD