Adrenocortical hormone
Adrenocortical hormones are a group of hormones produced by the adrenal cortex, a part of the adrenal gland. These hormones play a crucial role in the body's response to stress, metabolism, immune response, and other essential functions.
Overview
The adrenal cortex produces three types of hormones: glucocorticoids, mineralocorticoids, and androgens. Each of these hormones has a unique role in maintaining the body's homeostasis.
Glucocorticoids
Glucocorticoids are a type of hormone that plays a vital role in the body's response to stress. The most well-known glucocorticoid is cortisol, which helps regulate the body's use of fats, proteins, and carbohydrates.
Mineralocorticoids
Mineralocorticoids are hormones that help maintain the balance of salt and water in the body. The most important mineralocorticoid is aldosterone, which helps control blood pressure by managing the balance of potassium and sodium in the body.
Androgens
Androgens are a group of hormones that contribute to the development and maintenance of male sex characteristics. Although androgens are often thought of as male hormones, they also have important functions in the female body.
Production and Regulation
The production of adrenocortical hormones is regulated by the hypothalamus and the pituitary gland. The hypothalamus releases corticotropin-releasing hormone (CRH), which signals the pituitary gland to release adrenocorticotropic hormone (ACTH). ACTH then stimulates the adrenal cortex to produce and release adrenocortical hormones.
Disorders of the Adrenal Cortex
Disorders of the adrenal cortex can lead to overproduction or underproduction of adrenocortical hormones. These conditions can have serious effects on the body's ability to maintain homeostasis. Examples of these disorders include Addison's disease, Cushing's syndrome, and congenital adrenal hyperplasia.
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Contributors: Prab R. Tumpati, MD