ATF1

ATF1 (Activating Transcription Factor 1) is a protein that in humans is encoded by the ATF1 gene. It is a member of the leucine zipper family of DNA binding proteins and interacts with the cAMP response element binding protein (CREB). The encoded protein is involved in various cellular processes, including cell proliferation, transformation, and apoptosis.

Function

ATF1 is a transcription factor that binds to the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Studies in mice suggest that the protein encoded by this gene is important for the establishment of the blood-brain barrier, and may play a role in carrying out the normal functions of the hypothalamus.

Clinical significance

ATF1 is implicated in the development of several types of cancer, including melanoma, angiosarcoma, and lung cancer. It is also associated with FUS in liposarcoma and EWSR1 in clear cell sarcoma, which are both types of soft tissue sarcoma.

Interactions

ATF1 has been shown to interact with:

• CREB1
• JUN
• FOS
• DDIT3
• ATF2
• ATF3
• ATF4
• ATF6
• ATF7

See also

• Activating transcription factor
• cAMP responsive element binding protein
• Leucine zipper

External links

• ATF1 at the US National Library of Medicine Medical Subject Headings (MeSH)