ASA

ASA or Acetylsalicylic acid is a commonly used drug for the treatment of pain and fever due to various causes. It is also used in the prevention of heart attacks, strokes, and blood clot formation in people at high risk. It is in the family of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs) and works by inhibiting the production of body chemicals that cause pain, fever, and inflammation. It was first discovered by Felix Hoffmann, a German chemist, in 1897.

History

Felix Hoffmann, a German chemist, first synthesized acetylsalicylic acid in 1897 while working for Bayer. His work followed that of many others who had previously synthesized the compound. Hoffmann's work is often credited as the first synthesis of acetylsalicylic acid, but this is incorrect. The compound was first synthesized by French chemist Charles Frederic Gerhardt in 1853.

Uses

Acetylsalicylic acid is used to relieve pain, reduce inflammation, and lower fever. It is also used to prevent blood clots in the heart, brain, and lungs. This can help prevent a second heart attack or stroke in people with a history of these conditions.

Side Effects

Like all medications, acetylsalicylic acid can cause side effects. The most common side effects are gastrointestinal ulcers, stomach bleeding, and tinnitus, especially in higher doses. In children and adolescents, acetylsalicylic acid is not recommended due to the risk of Reye's syndrome.

Mechanism of Action

Acetylsalicylic acid works by irreversibly disabling the COX enzymes to block the formation of prostaglandins and thromboxanes, thereby reducing pain, inflammation, and fever.

See Also

• Nonsteroidal anti-inflammatory drug
• Felix Hoffmann
• Charles Frederic Gerhardt
• Reye's syndrome

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