AS-19 (drug)

AS-19 (drug)

Chemical structure of AS-19

AS-19 is a selective agonist for the 5-HT7 receptor, a subtype of the serotonin receptor family. It is primarily used in scientific research to study the role of the 5-HT7 receptor in various physiological and neurological processes.

Pharmacology

AS-19 exhibits high affinity and selectivity for the 5-HT7 receptor, which is a G protein-coupled receptor (GPCR) involved in the modulation of neurotransmitter release, circadian rhythm, and thermoregulation. The activation of 5-HT7 receptors by AS-19 has been shown to influence cognitive function, mood, and sleep-wake cycle.

Mechanism of Action

AS-19 acts as an agonist at the 5-HT7 receptor, meaning it binds to the receptor and activates it, mimicking the action of the natural ligand, serotonin. This activation leads to a cascade of intracellular events, primarily involving the increase of cyclic adenosine monophosphate (cAMP) levels, which in turn modulates various downstream signaling pathways.

Research Applications

AS-19 is utilized in neuroscience research to explore the therapeutic potential of 5-HT7 receptor modulation in treating psychiatric disorders such as depression, anxiety, and schizophrenia. Studies have also investigated its role in pain management and neuroprotection.

Related Pages

• Serotonin receptor
• 5-HT7 receptor
• G protein-coupled receptor
• Neurotransmitter